The new DynoChem Resources is live, using Microsoft Silverlight

The new DynoChem Resources webpage, the source for latest and best versions of all of our tools, went live on Friday 29 July.  There are lots of great features: sign up or sign in to see them.

Including search - across all types of content, with related items grouped so you can find everything you need in a few clicks:

And a preview pane - so you can make a good selection of the right tools for your project faster than ever:

DynoChem Resources 2011 is the result of listening to users; you asked for a single source for tools, training and supporting documents when starting new projects, that was easy to use and always up to date.

We use Microsoft's Silverlight plug-in to make the website easy to navigate, more powerful and perform like a desktop application program.

It's our best ever model library and it's integrated into every copy of DynoChem 2011.  We look forward to your feedback and further suggestions to make our tools even better.

Another fine GSK example shows how to make synergistic use of Kinetics and DOE

Mark Hughes and colleagues from GSK recently wrote up another fine example of the synergistic use of kinetics and design of experiments.

To quote the authors, "The DoE studies gave us an idea of the risks ... the kinetic model had provided higher-yielding conditions".

For more details, see:
A Mechanistic Insight into a Simple C-N Bond Formation via SN2 Displacement: A Synergistic Kinetics and Design of Experiment Approach.
Vol. 14, No. 6, 2010 / Organic Process Research & Development
in DynoChem Resources and the ACS website.

Q11 Draft Available

A draft of ICH Q11 covering Development and Manufacture of Drug Substances is now available here.

Opportunities to spread the word about DynoChem and make QbD a reality

Scale-up Systems is recruiting customer facing Technical Applications Consultants to support our growing business in North America, Europe and India. 

In this key position, you can help change how the pharmaceutical industry works, putting DynoChem predictive tools that are fit for purpose in the hands of chemists and engineers.

Applications to join our team are welcome.  More details here.

Model Citizen: A Talk with Steve Hearn of Scale-Up Systems

Simon Brooke interviews Joe Hannon at DynoChem 2011 User Meeting, London.

Updated tools for size distribution modeling in DynoChem Resources

As the final part of a general update of our crystallization tools over the last year, we have just updated the utilities and models for size distribution calculations in DynoChem Resources.

The CSD/CLD tools are primarily for academic research purposes, rather than industrial application.  This is for two main reasons: i) most industrial problems can be solved without modeling the number balance/size distribution and ii) quantitative interpretation of measured size data for modeling remains a challenge (see e.g. reference 1).  Our models include options to 'calibrate' e.g. CLD data to close the mass balance.

You can find out more by reading the related Knowledge Base article.

For an example of mainstream application of DynoChem to industrial crystallization problems, see our Crystallization training exercise instead (Operation 5 in the manufacturing stage).

References
1. Zai Qun Yu, Pui Shan Chow and Reginald B. H. Tan, Interpretation of Focused Beam Reflectance Measurement (FBRM) Data via Simulated Crystallization, Organic Process Research & Development 2008, 12, 646–654, http://pubs.acs.org/doi/abs/10.1021/op800063n