DynoChem Resources Update 67: Calculate vortex shape and baffle effects in vessel mixing utilities

Update 67 in November 2013 focused on the DynoChem mixing / vessel utilities, enhancing them to include detailed definition of baffle type and number and the associated calculations of vortex shape, wetted area and agitator power. To find out more:

• Download the KB Article describing the new calculations of vortex shape and baffle effects in the vessel / mixing utilities:https://dcresources.scale-up.com/Default.aspx?id=364
• Watch the recorded webinar: http://dcresources.scale-up.com/Recording.aspx?id=932

DynoChem web library update #66, September 2013: Drug dissolution models, slides from guest webinars, KB articles and enhancements

We update the DynoChem Resources (‘DCR’) website monthly with new tools/ applications and content that are immediately available to all users.  These updates and other news are announced on Twitter and you can keep up to date anytime by following us.

You can always stay up to date using the comprehensive WhatsNew.pdf summary.  

Update 66 this month included:

·         Slides from recent DynoChem guest webinars by customers from BMS, Merck and Reaction Science

·         New models for simulation of drug dissolution in a USP Apparatus:

o   under monophasic or biphasic (sink) conditions, for BCS Class II compounds

o   with competing disintegration and dissolution rates for immediate release formulations

·         New syntax in statements.xls for defining common reactions with SN1 or SN2 mechanisms, acid catalysis, pH variations and working with HPLC Area Percent data

·         New branches in the training tree for building a model step by step and then moving to consider process safety issues on scale-up

·         New KB articles and webinar recordings on use of HPLC data to build DynoChem models.

We hope that you find this update useful and will forward/ share it within your own organization with people who may be interested. 

Please note that we have upcoming public training events for New Users in Wilmington and San Francisco.

For the record, Updates 63-65 in the last 3 months included:

·         a whole new Library of flow chemistry models, with training and a PFR design utility;

·         new models for reactions (using carbonate base, Suzuki Coupling, optical resolution);

·         new calculations in the VLLE utility (ternary boiling point, mixture flash point);

·         new recorded webinars (e.g. BMS on QbD and Merck on extending the benefits of modeling across a department).

Boston Training: Get Started with Process Optimization and Scale-up using DynoChem (at Cambridge Residence Inn, Kendall Square)

Join the DynoChem training team for two days of hands-on training, using DynoChem to accelerate process development and scale-up projects.

Training will address DynoChem applications for engineers and scientists in API process development groups involved in tech transfer, troubleshooting and optimisation of API reaction, workup and isolation steps.  

The agenda will cover topics such as:

• Obtaining physical property values for solvents and mixtures
• Phase equilibrium calculations for boiling point, identifying azeotropes and miscibility
• Reactor calculations for heat transfer and mixing
• Optimising batch distillation / solvent switch operations
• Scale-up of filtration and centrifugation steps
• Basics of DynoChem modelling applicable to reactions, crystallization and other operations

Training times will be from 9:00 to 4:30 each day, with 6 hours of tuition.  Computers with DynoChem installed may be provided for your convenience - let us know if you will be needing one and we will confirm the cost. 

Learning objectives:

By the end of the course, trainees will be able to:

• Draw and understand process schemes and use them to help think about how to model or design experiments to understand a new or existing process
• Use DynoChem utilities to estimate parameter values, compare vessels and ensure minimum agitation criteria are met in lab and plant vessels
• Model chemical reactions, including kinetics, temperature-dependence, reaction orders
• Fit chemical kinetics to typical lab data
• Optimise reactions for yield and impurity levels
• Generate response surfaces to study process robustness and determine design space for QbD submissions
• Further develop initial models to include multi-phase, scale-up and interpretation of analytical data
• Use plant data to back out equipment characteristics, especially heat transfer
• Simulate solid-liquid separation operations based on standard lab experiments
• Look up physical properties for pure components and mixtures
• Simulate solvent swap / displacement / chasing operations to optimize solvent volumes and cycle time
• Understand more about how DynoChem works internally and how it builds the model from user input

• Explore other applications and reuse learned skills to tackle other unit operations or create new templates.

Event Registration Online for Boston Training: Get Started with Process Optimization and Scale-up using DynoChem powered by Eventbrite

And now, for something a bit different

If you are a regular on our YouTube Channel, you'll know that we go into technical detail when talking about using our software to support chemical development, scale-up and QbD.

Today we posted a 1-minute video cartoon animation that you may find amusing, interesting and helpful in explaining the potential of DynoChem to your colleagues.

If you like it, let us know by sharing it, emailing us, or the next time we see you.

AIChE QbD Awards 2013: Nominations close on 14 June

There is just one week left in which to make further nominations for the AIChE QbD Awards this year.  

Awards Chair Bob Yule of GSK has been promoting the nomination process and more nominations are welcome.  Apart from the Drug Substance and Drug Product awards, the Integrated award goes to someone who is speaking at AIChE 2013.  So if you get time, please take one last look at the abstracts and see if any speaker merits a nomination for this award.

Please also spread the word via your own networks.  More info at http://www.aiche.org/community/divisions-forums/pd2m.

Presentation at Zhangjiang Pharmaceutical Valley Science Corner event on Friday 24 May

We at Scale-up Systems are looking forward to visiting China next week, seeing customers and presenting DynoChem at a Zhangjiang Pharmaceutical Valley Science Corner event on 24 May.

This will include:

• DynoChem Introduction
• Application of DynoChem in Process Development and Scale-up
• Case studies and success stories from customers worldwide.

For more details about this event, or to attend in person, please contact Dongjie (Jack) Ma of ScienView, our value added reseller in China, at dongjie.ma@scienview.com.

Scale-up Systems and ScienView Team Up to Provide #DynoChem Process Development Tools to Chinese Pharma

Great news today for the Chinese pharma and life sciences industries.  DynoChem software, support and training will now be available locally in China through our Value Added Reseller, ScienView.  For more details, see the press release.